Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …
and influence cellular function via effects on membrane properties, and also by acting as a …
Specialized pro-resolving mediator network: an update on production and actions
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …
Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights
Neutrophil extracellular traps (NETs) have recently emerged as a newly recognized
contributor to venous and arterial thrombosis. These strands of DNA extruded by activated or …
contributor to venous and arterial thrombosis. These strands of DNA extruded by activated or …
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?
D Panigrahy, MM Gilligan, S Huang, A Gartung… - Cancer and metastasis …, 2020 - Springer
Abstract Severe coronavirus disease (COVID-19) is characterized by pulmonary hyper-
inflammation and potentially life-threatening “cytokine storms”. Controlling the local and …
inflammation and potentially life-threatening “cytokine storms”. Controlling the local and …
Carcinogenesis: Failure of resolution of inflammation?
A Fishbein, BD Hammock, CN Serhan… - Pharmacology & …, 2021 - Elsevier
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …
key characteristic of carcinogens. However, the failure of resolution of inflammation in …
Targeting neutrophils for promoting the resolution of inflammation
JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
Eicosanoids in inflammation in the blood and the vessel
A Yamaguchi, E Botta, M Holinstat - Frontiers in pharmacology, 2022 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …
Myeloperoxidase: regulation of neutrophil function and target for therapy
SA Rizo-Téllez, M Sekheri, JG Filep - Antioxidants, 2022 - mdpi.com
Neutrophils, the most abundant white blood cells in humans, are critical for host defense
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
G Livshits, A Kalinkovich - Ageing research reviews, 2019 - Elsevier
Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
A Othman, M Sekheri, JG Filep - The FEBS journal, 2022 - Wiley Online Library
Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …