Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …

Nature has evolved a unique mechanism of self-regulatory feedback loops that help in
maintaining an internal cellular environment conducive to growth, healing and metabolism …

A molecular keypad lock that displays photodynamic activity when exposed to glutathione
(GSH), esterase and light in the given order, is fabricated and its efficacy in drug resistant …

Cell-selective activity regulation of therapeutics is necessary for efficient personalized
treatments with minimal off-target effects. Here, the first example of a structurally simple …

Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents
functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are …

Three unique hydrazone‐based small‐molecule‐activatable photosensitizers were
designed and synthesized. Two of them work efficiently in a low‐pH environment …

In this work, an NIR-activated fluorescent dye naphthalimide-thioether-cyanine (NPSCY)
was developed for the photodynamic treatment of cancer cells. In this dye, naphthalimide …

In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was
analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G …

In this research, four new conjugated Bodipy (boron dipyrromethene) structures absorbing in
the near IR region have been synthesized and their photophysical, electrochemical …

A cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to
decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1α …