[HTML][HTML] Implications of advances in studies of O6-methylguanine-DNA-methyltransferase for tumor prognosis and treatment
Y Chen, W Qu, J Tu, H Qi - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
O6-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme, which reverses
the alkylation of guanine O6 through directtransfer of the methyl group, maintains the gene …
the alkylation of guanine O6 through directtransfer of the methyl group, maintains the gene …
Zinc as a plausible epigenetic modulator of glioblastoma multiforme
Glioblastoma Multiforme (GBM) is an aggressive brain tumor (WHO grade 4 astrocytoma)
with unknown causes and is associated with a reduced life expectancy. The available …
with unknown causes and is associated with a reduced life expectancy. The available …
Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India
Background Runt related transcription factor3 (RUNX3) is considered as a tumor suppressor
gene (TSG) that functions through the TGF-β dependent apoptosis. Promoter methylation of …
gene (TSG) that functions through the TGF-β dependent apoptosis. Promoter methylation of …
Epigenetic alterations in oesophageal cancer: expression and role of the involved enzymes
N Lopes, MP Correia, R Henrique… - International Journal of …, 2020 - mdpi.com
Oesophageal cancer is a life-threatening disease, accounting for high mortality rates. The
poor prognosis of this malignancy is mostly due to late diagnosis and lack of effective …
poor prognosis of this malignancy is mostly due to late diagnosis and lack of effective …
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in gastrointestinal cancers
Z Wu, J Dai, J Li, Z Zhang, X Shen - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Gastrointestinal (GI) cancer is a prevalent disease and is recognized as the primary cause of
cancer-related mortality globally. Therefore, there is an urgent need for novel diagnostic and …
cancer-related mortality globally. Therefore, there is an urgent need for novel diagnostic and …
Mutation, methylation and expression analysis of LIFR gene in Indian breast cancer patients
LIFR functions as a tumor suppressor and metastatic suppressor of breast cancer. The
present study investigates the status of LIFR gene in Indian breast cancer patients. A total of …
present study investigates the status of LIFR gene in Indian breast cancer patients. A total of …
Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis
J Huang, JY Luo, HZ Tan - Plos one, 2019 - journals.plos.org
Background In this research, an meta-analysis was performed for assessment of the
associations between O6-methyguanine-DNA methyltransferase (MGMT) promoter …
associations between O6-methyguanine-DNA methyltransferase (MGMT) promoter …
食管鳞状细胞癌O6-甲基鸟嘌呤-DNA甲基转移酶表达与CT影像及病理特征的相关性
张海龙， 郑欢欢， 周科峰 - 分子影像学杂志, 2021 - j-fzyx.com
目的探讨食管鳞状细胞癌O 6-甲基鸟嘌呤DNA 甲基转移酶(MGMT) 表达与CT
影像及临床病理特征之间的关系. 方法回顾性分析142 例手术切除的食管鳞状细胞癌术前胸部平 …
影像及临床病理特征之间的关系. 方法回顾性分析142 例手术切除的食管鳞状细胞癌术前胸部平 …
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma
R Tian, Y Lv, X Yang, L Cui, X Wu, C Liu, J Li… - Archives of Oral …, 2021 - Elsevier
Objective To explore the role of DNA methyltransferase 1 (DNMT1) in development and
progression of hypopharyngeal squamous carcinoma. Design A total of 32 hypopharyngeal …
progression of hypopharyngeal squamous carcinoma. Design A total of 32 hypopharyngeal …
[PDF][PDF] Role of DNA Repair in Genome Stability, Tumor Prevention, and Main Complications in Case of Repair Failure
MR Hayek, J Timmins - 2022 - videleaf.com
A preserved genome is essential for the preservation and continuation of life. DNA, however,
is known to be an intrinsically reactive molecule and is highly susceptible to chemical …
is known to be an intrinsically reactive molecule and is highly susceptible to chemical …