Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies
NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
An update: mechanisms of microRNA in primary open-angle glaucoma
Y Wang, L Niu, J Zhao, M Wang, K Li… - Briefings in functional …, 2021 - academic.oup.com
Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to
blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type …
blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type …
Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma
ML Risner, S Pasini, NR McGrady, DJ Calkins - Molecular Neurobiology, 2022 - Springer
Abstract The BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-
based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy …
based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy …
Sensitivity to extracellular potassium underlies type-intrinsic differences in retinal ganglion cell excitability
Neuronal type-specific physiologic heterogeneity can be driven by both extrinsic and
intrinsic mechanisms. In retinal ganglion cells (RGCs), which carry visual information from …
intrinsic mechanisms. In retinal ganglion cells (RGCs), which carry visual information from …
Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
ML Risner, S Pasini, NR McGrady… - Molecular …, 2021 - Springer
Background Early challenges to axonal physiology, active transport, and ultrastructure are
endemic to age-related neurodegenerative disorders, including those affecting the optic …
endemic to age-related neurodegenerative disorders, including those affecting the optic …
Axon hyperexcitability in the contralateral projection following unilateral optic nerve crush in mice
Optic neuropathies are characterized by degeneration of retinal ganglion cell axonal
projections to the brain, including acute conditions like optic nerve trauma and progressive …
projections to the brain, including acute conditions like optic nerve trauma and progressive …
Retinal ganglion cells adapt to ionic stress in experimental glaucoma
Introduction Identification of early adaptive and maladaptive neuronal stress responses is an
important step in developing targeted neuroprotective therapies for degenerative disease. In …
important step in developing targeted neuroprotective therapies for degenerative disease. In …
Uveitic glaucoma-like features in Yap conditional knockout mice
J Bitard, EK Grellier, S Lourdel, HP Filipe… - Cell Death …, 2024 - nature.com
Glaucoma is a multifactorial neurodegenerative disease characterized by the progressive
and irreversible degeneration of the optic nerve and retinal ganglion cells. Despite medical …
and irreversible degeneration of the optic nerve and retinal ganglion cells. Despite medical …
Intrinsic morphologic and physiologic development of human derived retinal ganglion cells in vitro
ML Risner, S Pasini, X Chamling… - … Vision Science & …, 2021 - tvst.arvojournals.org
Purpose: Human retinal ganglion cells (hRGC) derived from human pluripotent stem cells
are promising candidates to model, protect, and replace degenerating RGCs. Here, we …
are promising candidates to model, protect, and replace degenerating RGCs. Here, we …
The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of …
We report a three-pronged phenotypic evaluation of the bioprecursor prodrug 10β, 17β-
dihydroxyestra-1, 4-dien-3-one (DHED) that selectively produces 17β-estradiol (E2) in the …
dihydroxyestra-1, 4-dien-3-one (DHED) that selectively produces 17β-estradiol (E2) in the …