Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to
blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type …

Abstract The BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-
based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy …

Neuronal type-specific physiologic heterogeneity can be driven by both extrinsic and
intrinsic mechanisms. In retinal ganglion cells (RGCs), which carry visual information from …

Background Early challenges to axonal physiology, active transport, and ultrastructure are
endemic to age-related neurodegenerative disorders, including those affecting the optic …

Optic neuropathies are characterized by degeneration of retinal ganglion cell axonal
projections to the brain, including acute conditions like optic nerve trauma and progressive …

Introduction Identification of early adaptive and maladaptive neuronal stress responses is an
important step in developing targeted neuroprotective therapies for degenerative disease. In …

Glaucoma is a multifactorial neurodegenerative disease characterized by the progressive
and irreversible degeneration of the optic nerve and retinal ganglion cells. Despite medical …

Purpose: Human retinal ganglion cells (hRGC) derived from human pluripotent stem cells
are promising candidates to model, protect, and replace degenerating RGCs. Here, we …

We report a three-pronged phenotypic evaluation of the bioprecursor prodrug 10β, 17β-
dihydroxyestra-1, 4-dien-3-one (DHED) that selectively produces 17β-estradiol (E2) in the …