Unlocking the next generation of phage therapy: the key is in the receptors

FLG Altamirano, JJ Barr - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Phages need to attach to a receptor on the bacterial surface to initiate infection.•It
is not common practice to identify these receptors before phage therapy use.•Identifying …

Bacteriophages as Potential Tools for Detection and Control of Salmonella spp. in Food Systems

S Wei, R Chelliah, M Rubab, DH Oh, MJ Uddin, J Ahn - Microorganisms, 2019 - mdpi.com
The global problem of antibiotic resistance in bacteria is quickly developing in most
antibiotics used in hospitals and livestock. Recently, the infections with multi-drug resistant …

Phage cocktails–an emerging approach for the control of bacterial infection with major emphasis on foodborne pathogens

AD Teklemariam, R Al Hindi, I Qadri… - Biotechnology and …, 2023 - Taylor & Francis
Phage therapy has recently attracted a great deal of attention to counteract the rapid
emergence of antibiotic-resistant bacteria. In comparison to monophage therapy, phage …

A New Phage Cocktail Against Multidrug, ESBL-Producer Isolates of Shigella sonnei and Shigella flexneri with Highly Efficient Bacteriolytic Activity

K Shahin, M Bouzari, M Komijani… - Microbial Drug …, 2020 - liebertpub.com
The globally increasing incidence of antibiotic resistance in pathogenic microorganisms
such as Shigella, a cause of human acute gastrointestinal infections, calls for developing …

Diversity of Salmonella enterica phages isolated from chicken farms in Kenya

KMD Gunathilake, A Makumi, S Loignon… - Microbiology …, 2024 - Am Soc Microbiol
In this study, we describe the characterization of 67 Salmonella enterica phages isolated
from Kenya. Specifically, the phages were isolated from chicken feces as well as from swabs …

[HTML][HTML] Molecular characteristics of novel phage vB_ShiP-A7 infecting multidrug-resistant Shigella flexneri and Escherichia coli, and its bactericidal effect in vitro and …

J Xu, R Zhang, X Yu, X Zhang, G Liu, X Liu - Frontiers in Microbiology, 2021 - frontiersin.org
In recent years, increasing evidence has shown that bacteriophages (phages) can inhibit
infection caused by multidrug-resistant (MDR) bacteria. Here, we isolated a new phage …

Design of a Bacteriophage Cocktail Active against Shigella Species and Testing of Its Therapeutic Potential in Galleria mellonella

AA Filippov, W Su, KV Sergueev, RT Kevorkian… - Antibiotics, 2022 - mdpi.com
Shigellosis is a leading global cause of diarrheal disease and travelers' diarrhea now being
complicated by the dissemination of antibiotic resistance, necessitating the development of …

Bacteriophage therapy for challenging bacterial infections: Achievements, limitations and prospects for future clinical use by veterinary dermatologists

RA Squires - Veterinary Dermatology, 2021 - Wiley Online Library
Background Bacteriophages were discovered just over 100 years ago and have been used
to treat bacterial infections in animals since the 1920s. The antimicrobial resistance crisis …

Shigella-Controlled Human Infection Models: Current and Future Perspectives

KA Clarkson, CK Porter, KR Talaat, MC Kapulu… - 2022 - Springer
Shigella-controlled human infection models (CHIMs) are an invaluable tool utilized by the
vaccine community to combat one of the leading global causes of infectious diarrhea, which …

Physicochemical characterization of ten newly isolated phages against the foodborne pathogen Shigella flexneri

D Tomat, A Gonzalez, V Aquili… - Journal of Food …, 2022 - Wiley Online Library
Ten bacteriophages with lytic activity against Shigella flexneri were tested for their
resistance to physicochemical conditions found in food matrices. Phage viability and activity …