Molecular regulation of follicle-stimulating hormone synthesis, secretion and action

N Das, TR Kumar - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

A new pathway in the control of the initiation of puberty: the MKRN3 gene

AP Abreu, DB Macedo, VN Brito… - Journal of …, 2015 - jme.bioscientifica.com
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

GnRH—a key regulator of FSH

GA Stamatiades, RS Carroll, UB Kaiser - Endocrinology, 2019 - academic.oup.com
The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive
development and function. Activation of specific, high-affinity cell surface receptors (GnRH …

Regulation of reproduction via tight control of gonadotropin hormone levels

D Coss - Molecular and cellular endocrinology, 2018 - Elsevier
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …

Minireview: activin signaling in gonadotropes: what does the FOX say… to the SMAD?

J Fortin, L Ongaro, Y Li, S Tran, P Lamba… - Molecular …, 2015 - academic.oup.com
The activins were discovered and named based on their abilities to stimulate FSH secretion
and FSHβ (Fshb) subunit expression by pituitary gonadotrope cells. According to …

Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

Y Gao, X Bai, D Zhang, C Han, J Yuan, W Liu… - Nature structural & …, 2016 - nature.com
Abstract Elongation factor 4 (EF4) is a key quality-control factor in translation. Despite its
high conservation throughout evolution, EF4 deletion in various organisms has not yielded a …

Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells

G Schang, L Ongaro, E Brûlé, X Zhou, Y Wang… - Journal of Biological …, 2022 - ASBMB
Mammalian reproduction depends on the gonadotropins, follicle-stimulating hormone (FSH),
and luteinizing hormone, which are secreted by pituitary gonadotrope cells. The zinc-finger …

GnRH receptor expression and reproductive function depend on JUN in GnRH receptor‒expressing cells

CR Jonak, NM Lainez, U Boehm, D Coss - Endocrinology, 2018 - academic.oup.com
Gonadotropin-releasing hormone (GnRH) from the hypothalamus regulates synthesis and
secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the …

GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER

IR Thompson, NA Ciccone, Q Zhou, S Xu… - Molecular …, 2016 - academic.oup.com
The pulsatile release of GnRH regulates the synthesis and secretion of pituitary FSH and
LH. Two transcription factors, cAMP-response element-binding protein (CREB) and …

Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea

LNG Adami, M Moysés-Oliveira… - International Journal of …, 2023 - nature.com
Erectile dysfunction (ED) incidence is higher in patients with obstructive sleep apnea (OSA).
Studies have suggested that ED and OSA may activate similar pathways; however, few have …