Miniaturized chemical tags for optical imaging
Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …
reporters that can retain the molecular recognition properties and activity profiles of …
The role of Raman spectroscopy within quantitative metabolomics
C Lima, H Muhamadali… - Annual Review of …, 2021 - annualreviews.org
Ninety-four years have passed since the discovery of the Raman effect, and there are
currently more than 25 different types of Raman-based techniques. The past two decades …
currently more than 25 different types of Raman-based techniques. The past two decades …
Super-resolution SRS microscopy with A-PoD
Stimulated Raman scattering (SRS) offers the ability to image metabolic dynamics with high
signal-to-noise ratio. However, its spatial resolution is limited by the numerical aperture of …
signal-to-noise ratio. However, its spatial resolution is limited by the numerical aperture of …
Phase‐separated multienzyme compartmentalization for terpene biosynthesis in a prokaryote
Liquid–liquid phase separation (LLPS) forms biomolecular condensates or coacervates in
cells. Metabolic enzymes can form phase‐separated subcellular compartments that enrich …
cells. Metabolic enzymes can form phase‐separated subcellular compartments that enrich …
Quantitative stimulated Raman scattering microscopy: promises and pitfalls
B Manifold, D Fu - Annual Review of Analytical Chemistry, 2022 - annualreviews.org
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
powerful chemical imaging tool that shows promise in numerous biological and biomedical …
A decade of alkyne-tag Raman imaging (ATRI): applications in biological systems
S Bakthavatsalam, K Dodo, M Sodeoka - RSC Chemical Biology, 2021 - pubs.rsc.org
Alkyne functional groups have Raman signatures in a region (1800 cm− 1 to 2800 cm− 1)
that is free from interference from cell components, known as the “silent region”, and alkyne …
that is free from interference from cell components, known as the “silent region”, and alkyne …
Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window
The spinal cord accounts for the main communication pathway between the brain and the
peripheral nervous system. Spinal cord injury is a devastating and largely irreversible …
peripheral nervous system. Spinal cord injury is a devastating and largely irreversible …
Toward Raman subcellular imaging of endothelial dysfunction
A Adamczyk, E Matuszyk, B Radwan… - Journal of Medicinal …, 2021 - ACS Publications
Multiple diseases are at some point associated with altered endothelial function, and
endothelial dysfunction (ED) contributes to their pathophysiology. Biochemical changes of …
endothelial dysfunction (ED) contributes to their pathophysiology. Biochemical changes of …
Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity
WW Chen, GA Lemieux, CH Camp Jr… - Nature chemical …, 2020 - nature.com
Caenorhabditis elegans serves as a model for understanding adiposity and its connections
to aging. Current methodologies do not distinguish between fats serving the energy needs of …
to aging. Current methodologies do not distinguish between fats serving the energy needs of …
Imaging sub-cellular methionine and insulin interplay in triple negative breast cancer lipid droplet metabolism
Triple negative breast cancer (TNBC) is a particularly aggressive cancer subtype that is
difficult to diagnose due to its discriminating epidemiology and obscure metabolome. For the …
difficult to diagnose due to its discriminating epidemiology and obscure metabolome. For the …