Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving
the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic …

Rationale: Remote ischemic preconditioning (rIPC) with short episodes of
ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

The circulation of nitrogen in nature is a prerequisite for life on earth. In the nitrogen cycle
atmospheric nitrogen is fixated by bacteria into forms that can be utilized by plants and …

Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo
generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate …

In this review we consider the effects of endogenous and pharmacological levels of nitrite
under conditions of hypoxia. In humans, the nitrite anion has long been considered as …

Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and
nitrite now suggest a critical role for the microbiome in the development of cardiac and …