Application of carbon nanotubes in sensing/monitoring of pancreas and liver cancer
E Ahmadian, D Janas, A Eftekhari, N Zare - Chemosphere, 2022 - Elsevier
Liver and pancreatic tumors are among the third leading causes of cancer-associated death
worldwide. In addition to poor prognosis, both cancer types are diagnosed at advanced and …
worldwide. In addition to poor prognosis, both cancer types are diagnosed at advanced and …
Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
D Thomas, P Radhakrishnan - Molecular cancer, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that
produce desmoplastic stroma, thereby modulating disease progression and therapeutic …
produce desmoplastic stroma, thereby modulating disease progression and therapeutic …
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
[HTML][HTML] Microenvironmental determinants of pancreatic cancer
E Hessmann, SM Buchholz, IE Demir… - Physiological …, 2020 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
[HTML][HTML] Targeting the TGFβ pathway for cancer therapy
C Neuzillet, A Tijeras-Raballand, R Cohen… - Pharmacology & …, 2015 - Elsevier
The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation,
apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune …
apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune …
[HTML][HTML] The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
Q Sun, B Zhang, Q Hu, Y Qin, W Xu, W Liu, X Yu… - Theranostics, 2018 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most challenging lethal
tumors and has a very poor prognosis. In addition to cancer cells, the tumor …
tumors and has a very poor prognosis. In addition to cancer cells, the tumor …
[HTML][HTML] Tumor microenvironment in chemoresistance, metastasis and immunotherapy of pancreatic cancer
S Wang, Y Li, C Xing, C Ding, H Zhang… - American journal of …, 2020 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is a fatal disease with high malignancy and difficult for early
diagnosis. PC causes more than 400,000 patient deaths world widely and becomes the …
diagnosis. PC causes more than 400,000 patient deaths world widely and becomes the …
Retinoic acid–induced pancreatic stellate cell quiescence reduces paracrine Wnt–β-catenin signaling to slow tumor progression
BACKGROUND & AIMS: Patients with pancreatic ductal adenocarcinoma are deficient in
vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We investigated whether …
vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We investigated whether …
[HTML][HTML] Pancreatic stellate cell: Pandora's box for pancreatic disease biology
RR Bynigeri, A Jakkampudi, R Jangala… - World journal of …, 2017 - ncbi.nlm.nih.gov
Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …
attention after 1998 when the methods to isolate and culture them from murine and human …