Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Sampling alternative conformational states of transporters and receptors with AlphaFold2
Equilibrium fluctuations and triggered conformational changes often underlie the functional
cycles of membrane proteins. For example, transporters mediate the passage of molecules …
cycles of membrane proteins. For example, transporters mediate the passage of molecules …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
Structure of the human respiratory complex II
Z Du, X Zhou, Y Lai, J Xu, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Human complex II is a key protein complex that links two essential energy-producing
processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to …
processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to …
Advances in hydrogen/deuterium exchange mass spectrometry and the pursuit of challenging biological systems
EI James, TA Murphree, C Vorauer, JR Engen… - Chemical …, 2021 - ACS Publications
Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …
a widespread tool for structural analysis across academia and the biopharmaceutical …
CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …
computational microscopes, revealing coordinated events at the membrane interface. As G …
The solute carrier SPNS2 recruits PI (4, 5) P2 to synergistically regulate transport of sphingosine-1-phosphate
Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator
superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) …
superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) …
Bridging protein structure, dynamics, and function using hydrogen/deuterium‐exchange mass spectrometry
EA Hodge, MA Benhaim, KK Lee - Protein Science, 2020 - Wiley Online Library
Much of our understanding of protein structure and mechanistic function has been derived
from static high‐resolution structures. As structural biology has continued to evolve it has …
from static high‐resolution structures. As structural biology has continued to evolve it has …