Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide.
Although TBI leads to mechanical damage during initial impact, secondary damage also …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …

After a severe episode of ischemia, traumatic brain injury (TBI) or epilepsy, it is typical to find
necrotic cell death within the injury core. In addition, a substantial number of neurons in …

Apoptosis, or programmed cell death, is a physiological form of cell death that is important
for normal embryologic development and cell turnover in adult organisms. Cumulative …

Necroptosis is a newly described form of regulated necrosis that contributes to neuronal
death in experimental models of stroke and brain trauma. Although much work has been …

Traumatic brain injury (TBI) is a major cause of chronic disability and death in young adults
worldwide. Multiple cellular, molecular and biochemical changes impact the development …

Cerebral gene expressions change in response to traumatic brain injury (TBI), and future
trauma treatment may improve with increased knowledge about these regulations. We …