Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect

K Tsutsui, T Ubuka, GE Bentley, LJ Kriegsfeld - General and comparative …, 2012 - Elsevier
A hypothalamic neuropeptide, gonadotropin-releasing hormone (GnRH), is the primary
factor regulating gonadotropin secretion. An inhibitory hypothalamic neuropeptide for …

Seasonal control of gonadotropin-inhibitory hormone (GnIH) in birds and mammals

LJ Kriegsfeld, T Ubuka, GE Bentley, K Tsutsui - Frontiers in …, 2015 - Elsevier
Animals inhabiting temperate and boreal latitudes experience marked seasonal changes in
the quality of their environments and maximize reproductive success by phasing breeding …

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

M Kirilov, J Clarkson, X Liu, J Roa, P Campos… - Nature …, 2013 - nature.com
Signaling between kisspeptin and its receptor, G-protein-coupled receptor 54 (Gpr54), is
now recognized as being essential for normal fertility. However, the key cellular location of …

Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

T Ubuka, YL Son, K Tsutsui - General and comparative endocrinology, 2016 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that was isolated
from the brains of Japanese quail in 2000, which inhibited luteinizing hormone release from …

Gonadotropin-inhibitory hormone (GnIH): A new key neurohormone controlling reproductive physiology and behavior

K Tsutsui, T Ubuka - Frontiers in Neuroendocrinology, 2021 - Elsevier
The discovery of novel neurohormones is important for the advancement of
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …

Gonadotropin-inhibitory hormone (GnIH), GnIH receptor and cell signaling

T Ubuka, YL Son, GE Bentley, RP Millar… - General and comparative …, 2013 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) is an inhibitor of gonadotropin synthesis and
release, which was originally identified in the hypothalamus of the Japanese quail (Coturnix …

regulatory mechanisms of gonadotropin-inhibitory hormone (GnIH) synthesis and release in photoperiodic animals

K Tsutsui, T Ubuka, GE Bentley… - Frontiers in …, 2013 - frontiersin.org
Gonadotropin-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that was
discovered in quail as an inhibitory factor for gonadotropin release. GnIH inhibits …

Central and peripheral neuropeptide RFRP-3: a bridge linking reproduction, nutrition, and stress response

P Singh, S Anjum, RK Srivastava, K Tsutsui… - Frontiers in …, 2022 - Elsevier
This article is an amalgamation of the current status of RFRP-3 (GnIH) in reproduction and
its association with the nutrition and stress-mediated changes in the reproductive activities …

Functional implications of RFRP-3 in the central control of daily and seasonal rhythms in reproduction

E Angelopoulou, C Quignon, LJ Kriegsfeld… - Frontiers in …, 2019 - frontiersin.org
Adaptation of reproductive activity to environmental changes is essential for breeding
success and offspring survival. In mammals, the reproductive system displays regular cycles …

Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior

K Tsutsui, T Ubuka, K Ukena - Frontiers in Neuroendocrinology, 2022 - Elsevier
The discovery of gonadotropin-inhibitory hormone (GnIH) in 2000 has led to a new research
era of reproductive neuroendocrinology because, for a long time, researchers believed that …