The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

MR Mangalea, BR Borlee - Scientific reports, 2022 - nature.com
Burkholderia pseudomallei is a saprophytic bacterium endemic throughout the tropics
causing severe disease in humans and animals. Environmental signals such as the …

[HTML][HTML] Biofilm Signaling, Composition and Regulation in Burkholderia pseudomallei

PK Nyanasegran, S Nathan… - … of Microbiology and …, 2023 - ncbi.nlm.nih.gov
The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia
pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously …

N‐acetyl‐β‐hexosaminidase activity is important for chitooligosaccharide metabolism and biofilm formation in Burkholderia pseudomallei

CL Moran, A Debowski, A Vrielink… - Environmental …, 2024 - Wiley Online Library
Burkholderia pseudomallei is a saprophytic Gram‐negative bacillus that can cause the
disease melioidosis. Although B. pseudomallei is a recognised member of terrestrial soil …

Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a Burkholderia pseudomallei virulence factor important during …

JI Sanchez-Villamil, D Tapia, N Khakhum… - Gut …, 2022 - Taylor & Francis
Melioidosis is a disease caused by the Gram-negative bacillus Burkholderia pseudomallei
(Bpm), commonly found in soil and water of endemic areas. Naturally acquired human …

Burkholderia pseudomallei as an enteric pathogen: identification of virulence factors mediating gastrointestinal infection

JI Sanchez-Villamil, D Tapia, GI Borlee… - Infection and …, 2020 - Am Soc Microbiol
Burkholderia pseudomallei is a Gram-negative bacterium and the causative agent of
melioidosis. Despite advances in our understanding of the disease, B. pseudomallei poses …

Bacterial biofilms: Pathogenesis, monitoring, treatment approaches and associated challenges

S Dhiman, A Kumar, G Kaur, G Mukherjee, S Rustagi… - Biologia, 2024 - Springer
Recognition of the fact that bacterial biofilm might contribute to the development of diseases
has prompted a greater emphasis on identifying conditions, that could be linked to the …

Microbial exopolysaccharides: An introduction

KV Sajna, S Sharma, AK Nadda - Microbial exopolysaccharides as novel …, 2021 - Springer
Microbes secrete high molecular-weight polysaccharides of diverse structures into the
surrounding environment termed exopolysaccharides (EPSs). EPSs serve multifarious roles …

TetR-like regulator BP1026B_II1561 controls aromatic amino acid biosynthesis and intracellular pathogenesis in Burkholderia pseudomallei

IA McMillan, MH Norris, Y Heacock-Kang… - Frontiers in …, 2024 - frontiersin.org
Burkholderia pseudomallei (Bp) causes the tropical disease melioidosis that afflicts an
estimated 165,000 people each year. Bp is a facultative intracellular pathogen that transits …

The Bep gene cluster in Burkholderia cenocepacia H111 codes for a water-insoluble exopolysaccharide essential for biofilm formation

B Bellich, LC Terán, MM Fazli, F Berti, R Rizzo… - Carbohydrate …, 2023 - Elsevier
Burkholderia cenocepacia is an opportunistic pathogen isolated from cystic fibrosis patients
where it causes infections that are extremely difficult to treat with antibiotics, and sometimes …

Progress and Challenges for the Application of Machine Learning for Neglected Tropical Diseases

CY Khew, R Akbar, NM Assaad - arXiv preprint arXiv:2212.01027, 2022 - arxiv.org
Neglected tropical diseases (NTDs) continue to affect the livelihood of individuals in
countries in the Southeast Asia and Western Pacific region. These diseases have been long …