The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, infects one-third of
the world population. TB remains the leading cause of mortality due to a single bacterial …

Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency
and protein modification. Recent findings uncovered the allosteric function of ATP in cellular …

We review literature on the metabolism of ribo-and deoxyribonucleotides, nucleosides, and
nucleobases in Escherichia coli and Salmonella, including biosynthesis, degradation …

Growing antimicrobial resistance of the pathogens against multiple drugs posed a serious
threat to the human health worldwide. This fueled the need of identifying the novel …

The biosynthesis of isopentenyl diphosphate (IPP) from either the mevalonate (MVA) or the
1-deoxy-d-xylulose 5-phosphate (DXP) pathway provides the key metabolite for primary and …

The primary objective of this study was to better understand how root morphological
alteration stimulates N uptake in maize plants after root growth restriction, by investigating …

Enzymes from thermophilic organisms are interesting biocatalysts for a wide variety of
applications in organic synthesis, biotechnology, and molecular biology. Next to an …

Bacterial UMP kinases are essential enzymes involved in the multistep synthesis of UTP.
They are hexamers regulated by GTP (allosteric activator) and UTP (inhibitor). We describe …

The fosfomycin resistance protein FomA inactivates fosfomycin by phosphorylation of the
phosphonate group of the antibiotic in the presence of ATP and Mg (II). We report the crystal …

Isopentenyl phosphate kinase (IPK) catalyzes the Mg2+-ATP dependent phosphorylation
reactions to produce isopentenyl diphosphate, an important precursor in the synthesis of …