Structurally and functionally active synapses are essential for neurotransmission and for
maintaining normal synaptic and cognitive functions. Researchers have found that synaptic …

Alzheimer's disease (AD) is a progressive neurological disease characterized by the loss of
cognitive function, confusion, and memory deficit. Accumulation of abnormal proteins …

Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …

Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …

MicroRNAs (miRNAs) are found in nerve terminals, synaptic vesicles, and synaptosomes,
but it is unclear whether synaptic and cytosolic miRNA populations differ in Alzheimer's …

Background Mitochondrial dysfunction is a critical factor in the onset and progression of
neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as …

Synaptosomes are frequently used research objects in neurobiology studies focusing on
synaptic transmission as they mimic several aspects of the physiological synaptic functions …

The complex development of the human nervous system has been traditionally studied
using a combination of animal models, human post-mortem brain tissue, and human …

Localization of the N-methyl-D-aspartate type glutamate receptor (NMDAR) to dendritic
spines is essential for excitatory synaptic transmission and plasticity. Rather than remaining …

Motivational alterations, such as apathy, in HIV-1+ individuals are associated with
decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 …