Experimental binding energies in supramolecular complexes

F Biedermann, HJ Schneider - Chemical reviews, 2016 - ACS Publications
On the basis of many literature measurements, a critical overview is given on essential
noncovalent interactions in synthetic supramolecular complexes, accompanied by analyses …

Androgen receptor: structure, role in prostate cancer and drug discovery

MH Tan, J Li, HE Xu, K Melcher, E Yong - Acta Pharmacologica Sinica, 2015 - nature.com
Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Principles and applications of halogen bonding in medicinal chemistry and chemical biology

R Wilcken, MO Zimmermann, A Lange… - Journal of medicinal …, 2013 - ACS Publications
Halogen bonding has been known in material science for decades, but until recently,
halogen bonds in protein–ligand interactions were largely the result of serendipitous …

Thyroid hormone transporters

S Groeneweg, FS van Geest, RP Peeters… - Endocrine …, 2020 - academic.oup.com
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

Halogen bonding (X‐bonding): A biological perspective

MR Scholfield, CMV Zanden, M Carter… - Protein Science, 2013 - Wiley Online Library
The concept of the halogen bond (or X‐bond) has become recognized as contributing
significantly to the specificity in recognition of a large class of halogenated compounds. The …

Chemistry and biology in the biosynthesis and action of thyroid hormones

S Mondal, K Raja, U Schweizer… - Angewandte Chemie …, 2016 - Wiley Online Library
Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate,
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …

[HTML][HTML] Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster …

N Nader, GP Chrousos, T Kino - The FASEB Journal, 2009 - ncbi.nlm.nih.gov
Glucocorticoids, end products of the hypothalamic-pituitary-adrenal axis, influence functions
of virtually all organs and tissues through the glucocorticoid receptor (GR). Circulating levels …

Thyroid hormone receptor localization in target tissues

CS Anyetei-Anum, VR Roggero… - Journal of …, 2018 - joe.bioscientifica.com
The thyroid hormone receptors, TRα1, TRβ1 and other subtypes, are members of the
nuclear receptor superfamily that mediate the action of thyroid hormone signaling in …

The race to bash NASH: emerging targets and drug development in a complex liver disease

FA Romero, CT Jones, Y Xu, M Fenaux… - Journal of medicinal …, 2020 - ACS Publications
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …

Genomic and non-genomic mechanisms of action of thyroid hormones and their catabolite 3, 5-diiodo-l-thyronine in mammals

M Giammanco, CM Di Liegro, G Schiera… - International Journal of …, 2020 - mdpi.com
Since the realization that the cellular homologs of a gene found in the retrovirus that
contributes to erythroblastosis in birds (v-erbA), ie the proto-oncogene c-erbA encodes the …