Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …
Autophagy and ALS: mechanistic insights and therapeutic implications
JP Chua, H De Calbiac, E Kabashi, SJ Barmada - Autophagy, 2022 - Taylor & Francis
Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …
The sick and the weak: neuropathies/myopathies in the critically ill
O Friedrich, MB Reid, G Van den Berghe… - Physiological …, 2015 - journals.physiology.org
Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …
critical illness. Several weakness syndromes are summarized under the term intensive care …
RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders
Y Kitajima, K Yoshioka, N Suzuki - The Journal of Physiological Sciences, 2020 - Springer
Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
Autophagy is required to maintain muscle mass
The ubiquitin-proteasome and autophagy-lysosome pathways are the two major routes for
protein and organelle clearance. In skeletal muscle, both systems are under FoxO regulation …
protein and organelle clearance. In skeletal muscle, both systems are under FoxO regulation …
Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease
Autophagy, a vital catabolic process that degrades cytoplasmic components within the
lysosome, is an essential cytoprotective response to pathologic stresses that occur during …
lysosome, is an essential cytoprotective response to pathologic stresses that occur during …
Signaling in muscle atrophy and hypertrophy
M Sandri - Physiology, 2008 - journals.physiology.org
Muscle performance is influenced by turnover of contractile proteins. Production of new
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …
Signaling pathways in skeletal muscle remodeling
R Bassel-Duby, EN Olson - Annu. Rev. Biochem., 2006 - annualreviews.org
Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological
and metabolic parameters. It is this diversity that enables different muscle groups to provide …
and metabolic parameters. It is this diversity that enables different muscle groups to provide …
Intensive care unit-acquired weakness: not just another muscle atrophying condition
H Lad, TM Saumur, MS Herridge… - International journal of …, 2020 - mdpi.com
Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …