Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Finding faster and simpler ways to screen protein sequence space to enable the
identification of new biocatalysts for asymmetric synthesis remains both a challenge and a …

Reductive amination is one of the most important methods for the synthesis of chiral amines.
Here we report the discovery of an NADP (H)-dependent reductive aminase from Aspergillus …

Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …

Imine reductases catalyse the reductive amination of aldehydes or ketones with amines to
produce chiral amines—a key transformation in the preparation of fine chemicals and active …

Highlights•Imine reductases (IREDs) enable the asymmetric synthesis of amines from
imines.•The development of annotated sequence databases has led to the discovery of new …

Chiral amines are valuable constituents of many important pharmaceutical compounds and
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …

Enzymatic reductive amination, being a direct, selective and green methodology, has
attracted significant interest in a short period of time and is emerging as a powerful tool for …

Biocatalysis is a key technology in the pharmaceutical industry as it can provide efficient and
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …