The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …

Despite advances in therapy for rheumatic diseases, hydroxychloroquine remains almost
universally recommended for the treatment of systemic lupus erythematosus (SLE), and is …

Understanding the cell–cell interactions that control CNS development and function has
long been limited by the lack of methods to cleanly separate neural cell types. Here we …

Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …