Trans-omics: how to reconstruct biochemical networks across multiple 'omic'layers
We propose 'trans-omic'analysis for reconstructing global biochemical networks across
multiple omic layers by use of both multi-omic measurements and computational data …
multiple omic layers by use of both multi-omic measurements and computational data …
The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2
MA De Matteis, L Staiano, F Emma… - Nature Reviews …, 2017 - nature.com
Lowe syndrome is an X-linked disease that is characterized by congenital cataracts, central
hypotonia, intellectual disability and renal Fanconi syndrome. The disease is caused by …
hypotonia, intellectual disability and renal Fanconi syndrome. The disease is caused by …
The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
A system-wide understanding of cellular function requires knowledge of all functional
interactions between the expressed proteins. The STRING database aims to collect and …
interactions between the expressed proteins. The STRING database aims to collect and …
Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway …
Y Wang, X Lai, D Wu, B Liu, N Wang… - Stem cell research & …, 2021 - Springer
Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem
cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal …
cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal …
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells
M Berlak, E Tucker, M Dorel, A Winkler, A McGearey… - Molecular Cancer, 2022 - Springer
Background Development of resistance to targeted therapies has tempered initial optimism
that precision oncology would improve poor outcomes for cancer patients. Resistance …
that precision oncology would improve poor outcomes for cancer patients. Resistance …
[HTML][HTML] VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress
V Shoshan-Barmatz, EN Maldonado, Y Krelin - Cell stress, 2017 - ncbi.nlm.nih.gov
This review presents current knowledge related to VDAC1 as a multi-functional
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …
Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways
Ornithine δ-aminotransferase (OAT, EC 2.6. 1.13) catalyzes the transfer of the δ-amino
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …
Neuroblastoma treatment in the post-genomic era
Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest
cells and showing heterogeneous biological, morphological, genetic and clinical …
cells and showing heterogeneous biological, morphological, genetic and clinical …
Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
C Zheng, J Chen, Y Wu, X Wang, Y Lin, L Shu… - Frontiers in …, 2023 - frontiersin.org
Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …
Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease
Given superior analytical features, MS proteomics is well suited for the basic investigation
and clinical diagnosis of human disease. Modern MS enables detailed functional …
and clinical diagnosis of human disease. Modern MS enables detailed functional …