Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Diabetic kidney disease remains the most common cause of end-stage kidney disease in
the world. Despite reductions in incidence rates of myocardial infarction and stroke in people …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes
and is one of the main causes of end‐stage renal disease (ESRD) in many countries. The …

Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and
57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be …

Epidermal growth factor receptor (EGFR) activation impacts the physiology and
pathophysiology of the cardiovascular system, and inhibition of EGFR activity is emerging as …

Despite improvements in glycaemic and blood pressure control, and the efficacy of renin–
angiotensin system (RAS) blockade for proteinuria reduction, diabetic nephropathy is the …

Background and purpose: Mitophagy plays a significant role in the progression of diabetic
nephropathy (DN), although the regulatory mechanisms remain unclear. Recently …