A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis
elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode …

Comparative genome analyses indicate that every taxonomic group so far studied contains
10–20% of genes that lack recognizable homologs in other species. Do such 'orphan'or …

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in
innate immunity and have detected marked diversification relative to Drosophila …

We present an analysis of over 1,100 of the∼ 10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

Comparison of whole genomes has revealed large and frequent changes in the size of gene
families. These changes occur because of high rates of both gene gain (via duplication) and …

Comparison of the genomes and proteomes of the two diptera Anopheles gambiae and
Drosophila melanogaster, which diverged about 250 million years ago, reveals …

The determination of complete genome sequences provides us with an opportunity to
describe and analyze evolution at the comprehensive level of genomes. Here we compare …

Orphan genes are protein-coding regions that have no recognizable homolog in distantly
related species. A substantial fraction of coding regions in any genome sequenced consists …

Several statistical tests based on population genetic theory are used to identify genes that
have recently acquired a beneficial mutation. Here, I describe the extension of these tests to …

We discuss the problems in defining the extent of the proteomes for completely sequenced
eukaryotic organisms (ie the total number of protein-coding sequences), focusing on yeast …