Biofilm antimicrobial susceptibility through an experimental evolutionary lens

T Coenye, M Bové, T Bjarnsholt - NPJ biofilms and microbiomes, 2022 - nature.com
Experimental evolution experiments in which bacterial populations are repeatedly exposed
to an antimicrobial treatment, and examination of the genotype and phenotype of the …

Within-host evolution of bacterial pathogens during persistent infection of humans

A Grote, AM Earl - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Some persistent infections are linked to drug resistance and adverse outcomes
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …

Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients

A Llanos, P Achard, J Bousquet, C Lozano… - Scientific Reports, 2023 - nature.com
Pseudomonas aeruginosa is a common pathogen in cystic fibrosis (CF) patients and a major
contributor to progressive lung damage. P. aeruginosa elastase (LasB), a key virulence …

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance

P Laborda, S Lolle, S Hernando-Amado… - Nature …, 2024 - nature.com
Mutations in mexZ, encoding a negative regulator of the expression of the mexXY efflux
pump genes, are frequently acquired by Pseudomonas aeruginosa at early stages of lung …

Anti-Pseudomonas aeruginosa Vaccines and Therapies: An Assessment of Clinical Trials

MM Elmassry, JA Colmer-Hamood, J Kopel… - Microorganisms, 2023 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high
morbidity and mortality in cystic fibrosis (CF) and immunocompromised patients, including …

Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections

TM Hibbert, M Whiteley, SA Renshaw… - Critical reviews in …, 2023 - Taylor & Francis
Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in
people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF …

Impact of CFTR Modulation on Pseudomonas aeruginosa Infection in People With Cystic Fibrosis

EL Ledger, DJ Smith, JJ Teh, ME Wood… - The Journal of …, 2024 - academic.oup.com
Background Pseudomonas aeruginosa is a multidrug-resistant pathogen causing
recalcitrant pulmonary infections in people with cystic fibrosis (pwCF). Cystic fibrosis …

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

MJ Shepherd, T Fu, NE Harrington, A Kottara… - Nature Reviews …, 2024 - nature.com
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …

Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments

D Ruhluel, L Fisher, TE Barton, H Leighton… - The ISME …, 2024 - academic.oup.com
Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with
cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease …

Punica granatum sarcotesta lectin (PgTeL) inhibits Pseudomonas aeruginosa replication, viability, aggregation, and biofilms

PM da Silva, GRS Ferreira, AR da Silva… - South African Journal of …, 2024 - Elsevier
Pseudomonas aeruginosa is included in the ESKAPEE group, which includes pathogens
responsible for nosocomial infections. PgTeL is a lectin from pomegranate sarcotesta active …