Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …

The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …

Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …

The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Recently, various types of cultured cells have been used to research the mechanisms of
transport and metabolism of drugs. Although many studies using cultured cell systems have …

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation
during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in …

The RPMI 2650 cell line has been a subject of evaluation as a physiological and
pharmacological model of the nasal epithelial barrier. However, its suitability for drug …

Acute viral rhinosinusitis (viral ARS), or commonly referred to as the “common cold”, is
caused by respiratory viruses that cause disruption of the airway epithelial barrier and …

During the last decades several new drug formulations were developed to target the central
nervous system (CNS) from the nasal cavity. However, in these studies less attention was …