The structural role of the carrier protein–active controller or passive carrier

J Crosby, MP Crump - Natural product reports, 2012 - pubs.rsc.org
Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750 Common to all
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …

Bacterial long-chain polyunsaturated fatty acids: their biosynthetic genes, functions, and practical use

K Yoshida, M Hashimoto, R Hori, T Adachi, H Okuyama… - Marine drugs, 2016 - mdpi.com
The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-
PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well …

Depside bond formation by the starter-unit acyltransferase domain of a fungal polyketide synthase

L Chen, X Wei, Y Matsuda - Journal of the American Chemical …, 2022 - ACS Publications
Depsides are polyphenolic molecules comprising two or more phenolic acid derivatives
linked by an ester bond, which is called a depside bond in these molecules. Despite more …

Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage

RV Grindberg, T Ishoey, D Brinza, E Esquenazi… - PloS one, 2011 - journals.plos.org
Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel,
biomedically relevant natural products. To understand their biosynthetic origins as well as …

The uncommon enzymology of cis-acyltransferase assembly lines

AT Keatinge-Clay - Chemical reviews, 2017 - ACS Publications
The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is
comprehensively analyzed, with greater attention paid to less common phenomena. Diverse …

Uncovering the structures of modular polyketide synthases

KJ Weissman - Natural product reports, 2015 - pubs.rsc.org
Covering: up to 2014 The modular polyketide synthases (PKSs) are multienzyme proteins
responsible for the assembly of diverse secondary metabolites of high economic and …

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

A Nakabachi, J Piel, I Malenovský… - Genome biology and …, 2020 - academic.oup.com
Abstract The Asian citrus psyllid Diaphorina citri (Insecta: Hemiptera: Psylloidea), a serious
pest of citrus species worldwide, harbors vertically transmitted intracellular mutualists …

Enhanced production of polyunsaturated fatty acids by enzyme engineering of tandem acyl carrier proteins

S Hayashi, Y Satoh, T Ujihara, Y Takata, T Dairi - Scientific reports, 2016 - nature.com
In some microorganisms, polyunsaturated fatty acids (PUFAs) are biosynthesized by PUFA
synthases characterized by tandem acyl carrier proteins (ACPs) in subunit A. These ACPs …

Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant

M Chen, Q Liu, SS Gao, AE Young… - Proceedings of the …, 2019 - National Acad Sciences
Fungi have the potential to produce a large repertoire of bioactive molecules, many of which
can affect the growth and development of plants. Genomic survey of sequenced biofertilizer …

Polyketide β-branching: diversity, mechanism and selectivity

PD Walker, ANM Weir, CL Willis, MP Crump - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from
simple building blocks to generate a diverse range of often complex chemical structures with …