Current cancer immunotherapies are primarily predicated on αβ T cells, with a stringent
dependence on MHC-mediated presentation of tumour-enriched peptides or unique …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely activated
γδT cell population, which constituted∼ 40% of tumor-infiltrating T cells in human pancreatic …

Innate-like tissue-resident γδ T cell compartments capable of protecting against
carcinogenesis are well established in mice. Conversely, the degree to which they exist in …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Abstract γδ T cells are a small population of mostly tissue‐resident lymphocytes, with both
innate and adaptive properties. These unique features make them particularly attractive …

The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

Abstract γδ T cells represent a small population of overall T lymphocytes (0.5–5%) and have
variable tissue distribution in the body. γδ T cells can perform complex functions, such as …