Behcet's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions

E Alpsoy - The Journal of dermatology, 2016 - Wiley Online Library
Behçet's disease (BD) is a chronic, relapsing, inflammatory multisystem disease of unknown
etiology. Oral ulcers, genital ulcers, cutaneous lesions, and ocular and articular involvement …

[HTML][HTML] Behçet's disease: an overview of etiopathogenesis

P Leccese, E Alpsoy - Frontiers in immunology, 2019 - frontiersin.org
Behçet's disease (BD) is a systemic inflammatory disease with a chronic, relapsing-remitting
course of unknown etiology hallmarked predominantly by mucocutaneous lesions and …

Impact of systemic factors in shaping the periodontal microbiome

F Teles, Y Wang, G Hajishengallis… - Periodontology …, 2021 - Wiley Online Library
Since 2010, next‐generation sequencing platforms have laid the foundation to an exciting
phase of discovery in oral microbiology as it relates to oral and systemic health and disease …

[HTML][HTML] 'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

D McGonagle, SZ Aydin, A Gül, A Mahr… - Nature Reviews …, 2015 - nature.com
The spondyloarthropathies comprise ankylosing spondylitis (AS), reactive arthritis, psoriatic
arthritis (PsA) and arthritis associated with inflammatory bowel disease. In this Perspectives …

The immunogenetics of Behçet's disease: A comprehensive review

M Takeuchi, DL Kastner, EF Remmers - Journal of autoimmunity, 2015 - Elsevier
Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …

[HTML][HTML] Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility

M Takeuchi, N Mizuki, A Meguro, MJ Ombrello… - Nature …, 2017 - nature.com
Abstract We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …

[HTML][HTML] Identification of multiple genetic susceptibility loci in Takayasu arteritis

G Saruhan-Direskeneli, T Hughes, K Aksu… - The American Journal of …, 2013 - cell.com
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu
arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is …

[HTML][HTML] Pathogenesis of Behçet's disease: autoinflammatory features and beyond

A Gül - Seminars in immunopathology, 2015 - Springer
Behçet's disease (BD) is an inflammatory disorder of unknown aetiology characterised by
recurrent attacks affecting the mucocutaneous tissues, eyes, joints, blood vessels, brain and …

Behcet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity

MJ Ombrello, Y Kirino, PIW de Bakker… - Proceedings of the …, 2014 - National Acad Sciences
The HLA protein, HLA-B* 51, encoded by HLA-B in MHC, is the strongest known genetic risk
factor for Behçet disease (BD). Associations between BD and other factors within the MHC …

Update on the therapy of Behçet disease

Z Saleh, T Arayssi - Therapeutic advances in chronic …, 2014 - journals.sagepub.com
Behçet disease is a chronic inflammatory systemic disorder, characterized by a relapsing
and remitting course. It manifests with oral and genital ulcerations, skin lesions, uveitis, and …