Towards a unified model of SMC complex function
M Hassler, IA Shaltiel, CH Haering - Current Biology, 2018 - cell.com
Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …
Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture
A Cuadrado, A Losada - Current opinion in genetics & development, 2020 - Elsevier
Cohesin is a complex conserved in evolution that entraps DNA. Originally identified for its
role in sister chromatid cohesion, it is currently considered a key player in 3D genome …
role in sister chromatid cohesion, it is currently considered a key player in 3D genome …
Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA
Abstract Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin
complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D …
complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D …
Studying protein-DNA interactions using atomic force microscopy
EC Beckwitt, M Kong, B Van Houten - Seminars in cell & developmental …, 2018 - Elsevier
Atomic force microscopy (AFM) has made significant contributions to the study of protein-
DNA interactions by making it possible to topographically image biological samples. A …
DNA interactions by making it possible to topographically image biological samples. A …
High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL
3D chromatin organization plays a critical role in regulating gene expression, DNA
replication, recombination, and repair. While initially discovered for its role in sister …
replication, recombination, and repair. While initially discovered for its role in sister …
Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates
Proper chromosome alignment and segregation during mitosis depend on cohesion
between sister chromatids, mediated by the cohesin protein complex, which also plays …
between sister chromatids, mediated by the cohesin protein complex, which also plays …
Persistent telomere cohesion protects aged cells from premature senescence
K Azarm, A Bhardwaj, E Kim, S Smith - Nature communications, 2020 - nature.com
Human telomeres are bound by the telomere repeat binding proteins TRF1 and TRF2.
Telomere shortening in human cells leads to a DNA damage response that signals …
Telomere shortening in human cells leads to a DNA damage response that signals …
Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells
Z Daniloski, S Smith - Cancer research, 2017 - AACR
Sister chromatids are held together by cohesin, a tripartite ring with a peripheral SA1/2
subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The …
subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The …
TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA
The telomere specific shelterin complex, which includes TRF1, TRF2, RAP1, TIN2, TPP1
and POT1, prevents spurious recognition of telomeres as double-strand DNA breaks and …
and POT1, prevents spurious recognition of telomeres as double-strand DNA breaks and …
A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models
In the course of various biological processes, specific DNA-binding proteins must efficiently
find a particular target sequence/protein or a damaged site on the DNA. DNA-binding …
find a particular target sequence/protein or a damaged site on the DNA. DNA-binding …