Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …

The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX1 and OX2. Orexin receptors are capable of coupling to all four …

Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia
and plays a key role in the pathophysiology of diabetes. To stimulate the development of …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

In human peripheral blood, the neutrophil granulocytes (neutrophils) are the most abundant
white blood cells. These professional phagocytes are rapidly recruited from the bloodstream …

Abstract Background and Purpose Ayahuasca (AYA) is a botanical psychedelic with
promising results in observational and small clinical trials for depression, trauma and drug …

Abstract Background and Purpose Clozapine is an effective antipsychotic for treatment‐
resistant schizophrenia, but its discontinuation leads to discontinuation syndrome/catatonia …

Abstract Background and Purpose Doxorubicin is widely used in the treatment of malignant
tumours, but doxorubicin‐induced cardiotoxicity severely limits its clinical application …

Background and Purpose Psoriasis is an autoimmune inflammatory skin disease, featuring
microvascular abnormalities and elevated levels of bradykinin. Contact activation of Factor …

Background and purpose Endocannabinoids are lipid mediators, which elicit complex
biological effects that extend beyond the central nervous system. Tissue concentrations of …