Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,
which even result in dysfunction and death. Vascular regeneration or artificial vascular graft …

The ability to monitor diseases, therapies, and their effects on the body is a critical
component of modern care and personalized medicine. Real time monitoring can be …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Biomaterials play a critical role in engineering of tissue constructs, working as an artificial
extracellular matrix to support regeneration. Because the elastic stretchability is a major …

Polyester elastomers are soft, biodegradable and biocompatible and are commonly used in
various biomedical applications, especially in tissue engineering. These synthetic polyesters …

The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Poly (glycerol sebacate)(PGS) is a biodegradable polymer increasingly used in a variety of
biomedical applications. This polyester is prepared by polycondensation of glycerol and …

Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …