Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

Increased exposure to stress is associated with stress-related disorders, including
depression, anxiety, and neurodegenerative conditions. However, susceptibility to stress is …

Obsessive–compulsive disorder (OCD) is a debilitating mental health disorder characterized
by intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Dysbiosis, an …

Environment is known to substantially alter mental state and behaviour across the lifespan.
Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major …

Abstract The Signature Biobank is a longitudinal repository of biospecimen, psychological,
sociodemographic, and diagnostic data that was created in 2012. The Signature Consortium …

The gut-brain axis is a critical communication system influencing the interactions between
the gastrointestinal tract (GI) and the central nervous system (CNS). The gut microbiota plays …

Brain and gut barriers have been receiving increasing attention in health and diseases
including in psychiatry. Recent studies have highlighted changes in the blood–brain barrier …

This review examines the evidence supporting the role of dysbiosis in the development of
obses-sive-compulsive disorders (OCD). We review the molecular mechanisms and role of …

Major depressive disorder (MDD) and irritable bowel syndrome (IBS) are two chronic,
debilitating conditions that exhibit high rates of comorbidity. Recurrent stress and …

Major depressive disorder (MDD) is a major global health challenge compounded by a lack
of effective antidepressant therapies. Chronic stress is the main environmental risk factor for …