Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

The mouse has been a powerful force in elucidating the genetic basis of human physiology
and pathophysiology. From its beginnings as the model organism for cancer research and …

R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in
experimental populations derived from inbred lines. It is implemented as an add-on package …

QTL are quantitative trait loci: genetic loci that contribute to variation in a quantitative trait.
QTL mapping is the effort to identify QTL through an experimental cross. In this book, we …

We describe a general statistical framework for the genetic analysis of quantitative trait data
in inbred line crosses. Our main result is based on the observation that, by conditioning on …

Abstract Background The American Heart Association has recommended tail-cuff blood
pressure measurement for high-throughput experimental designs, including mutagenesis …

Obesity is closely associated with the metabolic syndrome, a combination of disorders
including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local …

Differential susceptibility to diabetic nephropathy has been observed in humans, but it has
not been well defined in inbred strains of mice. The present studies characterized the …

Cnidarians are among the simplest extant animals; however EST analyses reveal that they
have a remarkably high level of genetic complexity. In this article, we show that the full …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …