[HTML][HTML] Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong
clinical, genetic and pathological overlap. This review focuses on the current understanding …
clinical, genetic and pathological overlap. This review focuses on the current understanding …
The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis
AD Foster, SL Rea - Neural Regeneration Research, 2020 - journals.lww.com
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted
diseases with genotypic, pathological and clinical overlap. One such overlap is the presence …
diseases with genotypic, pathological and clinical overlap. One such overlap is the presence …
Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis
ST Ngo, RPA van Eijk, V Chachay… - … lateral sclerosis and …, 2019 - Taylor & Francis
Objective: Weight loss in amyotrophic lateral sclerosis (ALS) is associated with faster
disease progression and shorter survival. It has different possible causes, including loss of …
disease progression and shorter survival. It has different possible causes, including loss of …
Lower hypothalamic volume with lower body mass index is associated with shorter survival in patients with amyotrophic lateral sclerosis
Background and purpose Weight loss in patients with amyotrophic lateral sclerosis (ALS) is
associated with faster disease progression and shorter survival. Decreased hypothalamic …
associated with faster disease progression and shorter survival. Decreased hypothalamic …
ALS-associated TBK1 variant p. G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation
AD Foster, P Downing, E Figredo, N Polain… - Molecular and Cellular …, 2020 - Elsevier
Mutations affecting SQSTM1 coding for p62 and TANK-Binding Kinase 1 (TBK1) have been
implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
Loss of appetite in patients with amyotrophic lateral sclerosis is associated with weight loss and anxiety/depression
Y Wang, S Ye, L Chen, L Tang, D Fan - Scientific reports, 2021 - nature.com
Weight loss is common in patients with Amyotrophic lateral sclerosis (ALS), and associated
with disease progression. Loss of appetite has been shown to be a contributor to weight loss …
with disease progression. Loss of appetite has been shown to be a contributor to weight loss …
The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis
A Bampton, C McHutchison, K Talbot… - Brain and …, 2024 - Wiley Online Library
Objective To summarize and evaluate evidence pertaining to the clinical, genetic,
histopathological, and neuroimaging correlates of cognitive and behavioral dysfunction in …
histopathological, and neuroimaging correlates of cognitive and behavioral dysfunction in …
TBK1 variants in Chinese patients with amyotrophic lateral sclerosis: Genetic analysis and clinical features
B Zhao, Q Jiang, J Lin, Q Wei, C Li… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Haploinsufficiency of TANK‐binding kinase 1 (TBK1) loss‐of‐
function (LoF) variants has been shown to be pathogenic in amyotrophic lateral sclerosis …
function (LoF) variants has been shown to be pathogenic in amyotrophic lateral sclerosis …
SQSTM1/p62 在肌萎缩性侧索硬化和额颞痴呆发病机理中的作用
AD Foster, SL Rea - 中国神经再生研究(英文版), 2020 - sjzsyj.com.cn
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted
diseases with genotypic, pathological and clinical overlap. One such overlap is the presence …
diseases with genotypic, pathological and clinical overlap. One such overlap is the presence …
Investigating the role of TANK-binding kinase 1 in autophagy and amyotrophic lateral sclerosis
RP Toth - 2022 - figshare.mq.edu.au
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease
leading to death 3 to 5 years from symptom onset. Protein inclusions containing Tar DNA …
leading to death 3 to 5 years from symptom onset. Protein inclusions containing Tar DNA …