Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …
among the most frequent causes of disability and death worldwide. Current treatment …
Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process
M Toricelli, AAR Pereira, GS Abrao… - Neural regeneration …, 2021 - journals.lww.com
Aging is a dynamic and progressive process that begins at conception and continues until
death. This process leads to a decrease in homeostasis and morphological, biochemical …
death. This process leads to a decrease in homeostasis and morphological, biochemical …
Climate change and neurodegenerative diseases
The climate change induced global warming, and in particular the increased frequency and
intensity of heat waves, have been linked to health problems. Among them, scientific works …
intensity of heat waves, have been linked to health problems. Among them, scientific works …
Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury
X Tian, F Yan, J Zheng, X Cui, L Feng, S Li… - Analytical …, 2019 - ACS Publications
Carboxylesterase 2 (CES2), an endoplasmic reticulum (ER) located phase I enzyme, plays a
vital role in the metabolism of various endogenous and exogenous substances, and is …
vital role in the metabolism of various endogenous and exogenous substances, and is …
Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation
K Le, Z Song, J Deng, X Peng, J Zhang, L Wang… - Inflammation …, 2020 - Springer
Objective and design Microglia stimulated by oxygen glucose deprivation (OGD) were
treated with quercetin to investigate the effect on oxidative stress and the inflammatory …
treated with quercetin to investigate the effect on oxidative stress and the inflammatory …
[HTML][HTML] CYP46A1 activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice
AM Petrov, M Lam, N Mast, J Moon, Y Li, E Maxfield… - …, 2019 - Elsevier
Efavirenz, the FDA-approved anti-retroviral medication, is evaluated in the clinical trial in
patients with mild cognitive impairment or early dementia due to Alzheimer's disease …
patients with mild cognitive impairment or early dementia due to Alzheimer's disease …
Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy
RC Koehler, ZJ Yang, JK Lee… - Journal of Cerebral …, 2018 - journals.sagepub.com
Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …
Glial cell AMPA receptors in nervous system health, injury and disease
M Ceprian, D Fulton - International journal of molecular sciences, 2019 - mdpi.com
Glia form a central component of the nervous system whose varied activities sustain an
environment that is optimised for healthy development and neuronal function. Alpha-amino …
environment that is optimised for healthy development and neuronal function. Alpha-amino …
Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain
G Biouss, L Antounians, B Li, JS O'Connell… - Journal of …, 2019 - Springer
Background Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease
primarily affecting preterm neonates. Neonates with NEC suffer from a degree of …
primarily affecting preterm neonates. Neonates with NEC suffer from a degree of …
Temporal Characterization of Microglia‐Associated Pro‐and Anti‐Inflammatory Genes in a Neonatal Inflammation‐Sensitized Hypoxic‐Ischemic Brain Injury Model
ME Bernis, Y Schleehuber, M Zweyer… - Oxidative medicine …, 2022 - Wiley Online Library
Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …