Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process

M Toricelli, AAR Pereira, GS Abrao… - Neural regeneration …, 2021 - journals.lww.com
Aging is a dynamic and progressive process that begins at conception and continues until
death. This process leads to a decrease in homeostasis and morphological, biochemical …

Climate change and neurodegenerative diseases

P Bongioanni, R Del Carratore, S Corbianco… - Environmental …, 2021 - Elsevier
The climate change induced global warming, and in particular the increased frequency and
intensity of heat waves, have been linked to health problems. Among them, scientific works …

Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury

X Tian, F Yan, J Zheng, X Cui, L Feng, S Li… - Analytical …, 2019 - ACS Publications
Carboxylesterase 2 (CES2), an endoplasmic reticulum (ER) located phase I enzyme, plays a
vital role in the metabolism of various endogenous and exogenous substances, and is …

Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation

K Le, Z Song, J Deng, X Peng, J Zhang, L Wang… - Inflammation …, 2020 - Springer
Objective and design Microglia stimulated by oxygen glucose deprivation (OGD) were
treated with quercetin to investigate the effect on oxidative stress and the inflammatory …

[HTML][HTML] CYP46A1 activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice

AM Petrov, M Lam, N Mast, J Moon, Y Li, E Maxfield… - …, 2019 - Elsevier
Efavirenz, the FDA-approved anti-retroviral medication, is evaluated in the clinical trial in
patients with mild cognitive impairment or early dementia due to Alzheimer's disease …

Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy

RC Koehler, ZJ Yang, JK Lee… - Journal of Cerebral …, 2018 - journals.sagepub.com
Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …

Glial cell AMPA receptors in nervous system health, injury and disease

M Ceprian, D Fulton - International journal of molecular sciences, 2019 - mdpi.com
Glia form a central component of the nervous system whose varied activities sustain an
environment that is optimised for healthy development and neuronal function. Alpha-amino …

Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain

G Biouss, L Antounians, B Li, JS O'Connell… - Journal of …, 2019 - Springer
Background Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease
primarily affecting preterm neonates. Neonates with NEC suffer from a degree of …

Temporal Characterization of Microglia‐Associated Pro‐and Anti‐Inflammatory Genes in a Neonatal Inflammation‐Sensitized Hypoxic‐Ischemic Brain Injury Model

ME Bernis, Y Schleehuber, M Zweyer… - Oxidative medicine …, 2022 - Wiley Online Library
Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …