Nonmelanoma skin cancer is the leading cause of cancer in the United States. Cutaneous
squamous cell carcinoma is second only to basal cell carcinoma in prevalence and its …

A flood of new knowledge and discoveries in the basic science of keratins and keratinization
has appeared in the past several years. This review summarizes this recent information with …

The stratum corneum of the skin serves as an effective barrier for maintenance of the internal
milieu against the external environment. At the cell periphery of the stratum corneum is the …

Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the
basal/spinous layers and high levels in the stratum granulosum. Although changes in …

Abstract EPSTEIN–BARR virus (EBV), a human herpesvirus, is strongly linked with two
relatively rare forms of B-cell lymphoma and with a much more prevalent epithelial …

EPSTEIN–BARR virus, a human herpesvirus with oncogenic potential, infects two target
tissues in vivo: B lymphocytes, where the infection is largely non-productive1, and stratified …

Hyper-and hypovitaminosis A both provoke epithelial pathologies in animals and humans.
This suggests that a critical level of retinoic acid (RA) is required in vivo for the maintenance …

We have previously shown that loricrin is a major component of the cornified cell envelope
(CE) expressed late in epidermal differentiation in the granular layers of normal skin. Normal …

The technology for culture of epidermis is one of the most advanced to date for generation of
a tissue in vitro. Cultured epidermis is already used for a number of applications ranging …

Transglutaminases (TGases) are seven enzymes, cross-linking proteins by γ-glutamil-ε-
lysine bonds, four of which are expressed in the skin. A new member of the TGase family …