A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

Hematopoietic stem cell (HSC) aging is accompanied by hematopoietic reconstitution
dysfunction, including loss of regenerative and engraftment ability, myeloid differentiation …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …

Infections are associated with extensive platelet consumption, representing a high risk for
health. However, the mechanism coordinating the rapid regeneration of the platelet pool …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability,
integrity, and ability to provide protection for the body. Some areas of skin are continuously …