Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Diabetes is a common endocrine disorder with an ever increasing prevalence globally,
placing significant burdens on our healthcare systems. It is associated with significant …

Background: The ability to increase heart rate during exercise and other stressors is a key
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …

Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence of
treatment. Among the diabetes-associated complications, cardiovascular disease is the …

Cardiac arrhythmias are associated with cardiovascular morbidity and mortality. Cardiac
electrophysiology studies (EPS) use intracardiac catheter recording and stimulation for …

Atrial fibrillation (AF), the most common sustained arrhythmia, is closely intertwined with
metabolic abnormalities. Recently, a metabolic paradox in AF pathogenesis has been …

Diabetes mellitus type 2 is associated with adverse clinical outcome after myocardial
infarction. To better understand the underlying causes we here investigated sarcomere …

The sinoatrial node (SAN) is composed of highly specialized cells that mandate the
spontaneous beating of the heart through self-generation of an action potential (AP). Despite …

Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-
threatening cardiac arrhythmias. Because the underlying mechanisms and potential …

Background Type 2 diabetes is associated with abnormal electrical conduction and sudden
cardiac death, but the pathogenic mechanism remains unknown. This study describes …