[HTML][HTML] Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
[PDF][PDF] Damage-associated molecular patterns in inflammatory diseases
JS Roh, DH Sohn - Immune network, 2018 - synapse.koreamed.org
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that
are released from damaged or dying cells and activate the innate immune system by …
are released from damaged or dying cells and activate the innate immune system by …
[HTML][HTML] Blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy
X Peng, Z Luo, S He, L Zhang, Y Li - Frontiers in cellular and infection …, 2021 - frontiersin.org
As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor
B Mei, J Li, Z Zuo - Brain, Behavior, and Immunity, 2021 - Elsevier
Sepsis-associated encephalopathy (SAE) is a significant clinical issue that is associated
with increased mortality and cost of health care. Dexmedetomidine, an α2 adrenoceptor …
with increased mortality and cost of health care. Dexmedetomidine, an α2 adrenoceptor …
[HTML][HTML] HMGB1: a common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction
High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia
and neurons upon inflammasome activation and activates receptor for advanced glycation …
and neurons upon inflammasome activation and activates receptor for advanced glycation …
[HTML][HTML] Impact of HMGB1, RAGE, and TLR4 in Alzheimer's disease (AD): from risk factors to therapeutic targeting
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …
[HTML][HTML] Can an infection hypothesis explain the beta amyloid hypothesis of Alzheimer's disease?
Alzheimer's disease (AD) is the most frequent type of dementia. The pathological hallmarks
of the disease are extracellular senile plaques composed of beta-amyloid peptide (Aβ) and …
of the disease are extracellular senile plaques composed of beta-amyloid peptide (Aβ) and …
The gut microbiome and Alzheimer's disease: Complex and bidirectional interactions
R Tarawneh, E Penhos - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …
[HTML][HTML] High mobility group box-1 and blood–brain barrier disruption
M Nishibori, D Wang, D Ousaka, H Wake - Cells, 2020 - mdpi.com
Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …