The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

The microRNA (miRNA)-34a is a key regulator of tumor suppression. It controls the
expression of a plethora of target proteins involved in cell cycle, differentiation and …

Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …

Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR
family. The biological functions are complex and diverse. PPARγ plays a significant role in …

The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

Hepatocellular carcinoma (HCC) is the third cause of cancer-related deaths worldwide.
Sorafenib is the only approved drug for patients with advanced HCC but has shown limited …

The important goal of cancer drug discovery is to develop therapeutic agents that are
effective, safe, and affordable. In the present study, we demonstrated that alantolactone …

Abstract Resistance to 5-fluorouracil (5-FU), an important anticancer drug, is a serious
challenge in the treatment of pancreatic cancer. Equilibrative nucleoside transporter 1 and …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is a central hub for the regulation of cell proliferation, apoptosis, cell cycle …