Extracellular vesicles in immunomodulation and tumor progression

C Marar, B Starich, D Wirtz - Nature immunology, 2021 - nature.com
Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …

Exosome-based immunotherapy: a promising approach for cancer treatment

Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …

Immune cell-derived extracellular vesicles–functions and therapeutic applications

RE Veerman, GG Akpinar, M Eldh… - Trends in molecular …, 2019 - cell.com
Extracellular vesicles (EVs) are nano-sized vesicles with the capacity to transfer nucleic
acids, proteins, and lipids, and are released by all cells. EV is an umbrella term for …

Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles

O Staufer, F Dietrich, R Rimal, M Schröter, S Fabritz… - Science …, 2021 - science.org
Extracellular vesicles (EVs) are fundamental for intercellular communication and influence
nearly every process in cell physiology. However, because of their intricate molecular …

Regulatory T cell-derived extracellular vesicles modify dendritic cell function

SL Tung, DA Boardman, M Sen, M Letizia, Q Peng… - Scientific Reports, 2018 - nature.com
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and
limit other immune responses. They achieve this through different mechanisms including the …

Extracellular vesicles as therapeutic resources in the clinical environment

J Sanz-Ros, C Mas-Bargues, N Romero-García… - International journal of …, 2023 - mdpi.com
The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules
between cells has raised the possibility to use them as therapeutic vehicles. The …

Treg-cell-derived IL-35-coated extracellular vesicles promote infectious tolerance

JA Sullivan, Y Tomita, E Jankowska-Gan, DA Lema… - Cell reports, 2020 - cell.com
Summary Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-
Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 …

[HTML][HTML] Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

JM Essola, M Zhang, H Yang, F Li, B Xia… - Bioactive Materials, 2024 - Elsevier
Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

The biology and function of extracellular vesicles in immune response and immunity

R Kalluri - Immunity, 2024 - cell.com
Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins
and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into …

Roles of exosomes derived from immune cells in cardiovascular diseases

R Wu, W Gao, K Yao, J Ge - Frontiers in Immunology, 2019 - frontiersin.org
Therapies aimed at minimizing adverse remodeling in cardiovascular diseases on a
molecular and cellular basis are urgently needed. Exosomes are nanosized lipid vesicles …