Proteins to be secreted through so-called “conventional mechanisms” are characterized by
the presence of an N-terminal peptide that is a leader or signal peptide, needed for access …

Amyloidosis is a common pathological event in which proteins self-assemble into misfolded
soluble and insoluble molecular forms, oligomers and fibrils that are often toxic to cells …

Cases of Type 2 Diabetes Mellitus (T2DM) are increasing at an alarming rate due to the rise
in obesity, sedentary lifestyles, glucose-rich diets and other factors. Numerous studies have …

Aims/hypothesis Apart from its fibrinolytic activity, the tissue plasminogen activator
(tPA)/plasmin system has been reported to cleave the peptide amyloid beta, attenuating …

Amyloid-proteinopathy is observed in type 2 diabetes, where Islet amyloid polypeptide is
secreted atypically and impedes cellular homeostasis. The thiazolidinediones family is …

Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also
aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease …

Sorting-related receptor with type A repeats (SORLA) is a sorting receptor encoded by
SORL1, a major risk gene for Alzheimer disease (AD). SORLA is protective against AD by …

Amylin, also known as islet amyloid polypeptide (IAPP), is a metabolic homeostasis-related
hormone that is produced and released by the β cells of the pancreas, the same cells that …

Given that the number of people who are diagnosed with diabetes continues to rise at an
alarming rate, there is a pressing need for therapeutic interventions that are either more …

Islet amyloid polypeptide (IAPP) is a neuroendocrine hormone from pancreatic β-cells.
Misfolded, aggregated IAPP is believed to be toxic to islet cells and amyloid deposits in the …