Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Upgrading wastewater treatment plants (WWTPs) with advanced technologies is one key
strategy to reduce micropollutant emissions. Given the complex chemical composition of …

Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Background: Studies characterizing associations between phenols, phthalates and thyroid
hormones during pregnancy produce inconsistent results. This divergence may be partly …

Background: Thyroid hormone receptors (TRs) are critical endocrine receptors that regulate
a multitude of processes in adult and developing organisms, and thyroid hormone disruption …

Background: House dust contains many organic contaminants that can compete with the
thyroid hormone (TH) thyroxine (T 4) for binding to transthyretin (TTR). How these …

Purpose Iodine is an essential micronutrient required for thyroid hormone biosynthesis.
However, overtreatment with iodine can unfavorably affect thyroid physiology. The aim of …

The environmental contaminant perchlorate impairs the synthesis of thyroid hormones by
reducing iodine uptake into the thyroid gland. Despite this known action, moderate doses of …

Deiodinase enzymes play an essential role in converting thyroid hormones between active
and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone …