Neural stem cell therapies and hypoxic-ischemic brain injury
Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …
The emerging role of leukemia inhibitory factor in cancer and therapy
Leukemia inhibitory factor (LIF) is a multi-functional cytokine of the interleukin-6 (IL-6)
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …
Effect of neuroinflammation on synaptic organization and function in the developing brain: implications for neurodevelopmental and neurodegenerative disorders
The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play
important roles in shaping and wiring neural connections. The perinatal period constitutes a …
important roles in shaping and wiring neural connections. The perinatal period constitutes a …
Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 (IL-6)
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …
Home sweet home: the neural stem cell niche throughout development and after injury
RM Ruddy, CM Morshead - Cell and tissue research, 2018 - Springer
Neural stem cells and their progeny reside in two distinct neurogenic niches within the
mammalian brain: the subventricular zone and the dentate gyrus. The interplay between the …
mammalian brain: the subventricular zone and the dentate gyrus. The interplay between the …
Sphingosine 1‐phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes
Abstract Sphingosine 1‐phosphate (S1P) is an essential lipid metabolite that signals
through a family of five G protein‐coupled receptors, S1PR1‐S1PR5, to regulate cell …
through a family of five G protein‐coupled receptors, S1PR1‐S1PR5, to regulate cell …
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Studies of heterochronic parabiosis demonstrated that with age, the composition of the
circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In …
circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In …
Pediatric brain repair from endogenous neural stem cells of the subventricular zone
Y Niimi, SW Levison - Pediatric research, 2018 - nature.com
There is great interest in the regenerative potential of the neural stem cells and progenitors
that populate the germinal zones of the immature brain. Studies using animal models of …
that populate the germinal zones of the immature brain. Studies using animal models of …
Leukemia inhibitory factor: Recent advances and implications in biotechnology
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine with several functions in health and
disease ranging from inflammation to cancer. LIF is also a potential target and/or therapeutic …
disease ranging from inflammation to cancer. LIF is also a potential target and/or therapeutic …
The role of the leukemia inhibitory factor receptor in neuroprotective signaling
SM Davis, KR Pennypacker - Pharmacology & therapeutics, 2018 - Elsevier
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor
receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce …
receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce …