Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Chimeric antigen receptor (CAR) T cell therapy has offered cancer patients a new alternative
therapeutic choice in recent years. This novel type of therapy holds tremendous promise for …

Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …

Whereas protease inhibitors have been developed successfully against hypertension and
viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling …

To achieve effective chemotherapy, many types of drug delivery systems have been
developed for the specific environments in tumor tissues. Polymer–drug conjugates are …

The tumor microenvironment is the cellular environment that is also described as the “soil”
for supporting tumor growth, proliferation, invasion and metastasis, as well as protecting …

Ilamycins/rufomycins are marine cycloheptapeptides containing unusual amino acids.
Produced by Streptomyces sp., these compounds show potent activity against a range of …

Protease–protease interactions lie at the heart of the biological cascades that provide rapid
molecular responses to living systems. Blood clotting cascades, apoptosis signaling …

Abstract 3D bioprinting often involves application of highly concentrated polymeric bioinks to
enable fabrication of stable cell‐hydrogel constructs, although poor cell survival …