Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Purpose Neurocritical care patients receive prolonged invasive mechanical ventilation
(IMV), but there is poor specific information in this high-risk population about the liberation …

Importance Many patients with severe stroke have impaired airway protective reflexes,
resulting in prolonged invasive mechanical ventilation. Objective To test whether early vs …

Mechanical ventilation is a life-support system used to ensure blood gas exchange and to
assist the respiratory muscles in ventilating the lung during the acute phase of lung disease …

Background In COVID-19 patients with acute respiratory distress syndrome (ARDS), the
effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy …

Purpose The effect of high arterial oxygen levels and supplemental oxygen administration
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …

To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential.
Cerebral tissue oxygenation represents the balance between oxygen supply and …

Background Severe traumatic brain-injured (TBI) patients should be primarily admitted to a
hub trauma center (hospital with neurosurgical capabilities) to allow immediate delivery of …

Background There is insufficient evidence to guide ventilatory targets in acute brain injury
(ABI). Recent studies have shown associations between mechanical power (MP) and …