With the discovery of the CFTR gene in 1989, the search for therapies to improve the basic
defects of cystic fibrosis (CF) commenced. Pharmacological manipulation provides the …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …

Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …

Background Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
gene lead to the disease cystic fibrosis (CF). Although patients with CF often have …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

TMEM16A is a Ca2+-activated chloride channel that was shown to enhance production and
secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly …

Key points Ano1, a Ca2+‐activated Cl− channel, is expressed in interstitial cells of Cajal
(ICC) throughout the gut. We report here that it is required to maintain coordinated Ca2+ …

Abstract Anoctamin 6 (Ano6; TMEM16F gene) is a ubiquitous protein; the expression of
which is defective in patients with Scott syndrome, an inherited bleeding disorder based on …

Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable
phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−] i) …