Proanthocyanidins: components, pharmacokinetics and biomedical properties

YX Zeng, S Wang, L Wei, YY Cui… - The American Journal of …, 2020 - World Scientific
Proanthocyanidins (PAs) are a group of polyphenols enriched in plant and human food. In
recent decades, epidemiological studies have upheld the direct relationship between PA …

Leukemia therapy by flavonoids: Future and involved mechanisms

R Saraei, F Marofi, A Naimi, M Talebi… - Journal of cellular …, 2019 - Wiley Online Library
Flavonoids are a varied family of phytonutrients (plant chemicals) usually are detected in
fruits and vegetables. In this big family, there exist more than 10,000 members that is …

Therapeutic inhibition of Staphylococcus aureus ArlRS two-component regulatory system blocks virulence

JM Kwiecinski, DA Jelani, EJ Fuentes… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Staphylococcus aureus is a common cause of severe infections, and its widespread
antibiotic resistance necessitates search for alternative therapies, such as inhibition of …

Chlorinated guaiane-type sesquiterpene lactones as cytotoxic agents against human tumor cells

F Estévez-Sarmiento, E Saavedra… - International Journal of …, 2020 - mdpi.com
Guaiane-type sesquiterpene lactones are naturally occurring compounds which have
attracted attention due to their array of biological activities. In this study, chlorinated …

Biological evaluation of optically pure chiral binuclear copper (II) complexes based on a rosin derivative as highly potential anticancer agents

BL Fei, S Tu, Z Wei, P Wang, JY Long, C Qiao… - Dalton …, 2019 - pubs.rsc.org
Two optically pure chiral binuclear copper (II) complexes [Cu2 (μ-Cl) 2L2]· CH2Cl2 (1) and
Cu2L4 (2) based on the natural product rosin derivative N-(5-dehydroabietyl-1, 3, 4 …

Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells

F Estévez-Sarmiento, E Saavedra, I Brouard… - International Journal of …, 2022 - mdpi.com
In this study, we investigated the effects of eleven synthetic guanidines containing the 1, 3-
diphenylpropenone core on the viabilities of six human cancer cells. The most cytotoxic …

6′-Benzyloxy-4-bromo-2′-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8-and reactive oxygen species-dependent apoptosis

E Saavedra, H Del Rosario, I Brouard… - Chemico-Biological …, 2019 - Elsevier
In this study, we investigated the effects of synthetic 6′-benzyloxy-4-bromo-2′-
hydroxychalcone on viabilities of seven human leukaemia cells. It was cytotoxic against U …

[HTML][HTML] Structure-activity relationships reveal a 2-furoyloxychalcone as a potent cytotoxic and apoptosis inducer for human U-937 and HL-60 leukaemia cells

H Del Rosario, E Saavedra, I Brouard… - Bioorganic …, 2022 - Elsevier
Synthetic flavonoids with new substitution patterns have attracted attention as potential
anticancer drugs. Here, twelve chalcones were synthesized and their antiproliferative …

Design and synthesis of naphthylchalcones as novel anti-leukaemia agents

EPT Leitão, OS Ascenso, TS de Almeida, I González… - Bioorganic …, 2021 - Elsevier
A series of new hydroxylated chalcone derivatives with different substitution patterns on a
phenyl ring A and B, were prepared by Claisen–Schmidt condensation in an aqueous …

The synthetic flavanone 6-methoxy-2-(naphthalen-1-yl) chroman-4-one induces apoptosis and activation of the MAPK pathway in human U-937 leukaemia cells

E Saavedra, H Del Rosario, I Brouard… - Bioorganic …, 2020 - Elsevier
Synthetic flavonoids containing a naphthalene ring have attracted attention as potential
cytotoxic compounds. Here, we synthesized ten chalcones and their corresponding …