Sepsis diagnosis and monitoring–procalcitonin as standard, but what next?

M Mierzchała-Pasierb… - Anaesthesiology intensive …, 2019 - termedia.pl
Sepsis is a life-threatening organ dysfunction caused by a systemic altered host response to
infection. According to the newest guidelines the sepsis treatment should be personalized …

Protective role of kallistatin in vascular and organ injury

J Chao, G Bledsoe, L Chao - Hypertension, 2016 - Am Heart Assoc
534 Hypertension September 2016 vasodilation is unrelated to the tissue kallikrein–kinin
system. 18 In addition, kallistatin transgenic mice were found to have significantly lower …

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

R An, L Zhao, C Xi, H Li, G Shen, H Liu… - Basic Research in …, 2016 - Springer
Myocardial dysfunction is an important manifestation of sepsis. Previous studies suggest that
melatonin is protective against sepsis. In addition, activation of the phosphatidylinositol 3 …

Protective role of endogenous kallistatin in vascular injury and senescence by inhibiting oxidative stress and inflammation

J Chao, Y Guo, L Chao - Oxidative Medicine and Cellular …, 2018 - Wiley Online Library
Kallistatin was identified in human plasma as a tissue kallikrein‐binding protein and a serine
proteinase inhibitor. Kallistatin exerts pleiotropic effects on angiogenesis, oxidative stress …

Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Z Fang, G Shen, Y Wang, F Hong, X Tang… - … and Targeted Therapy, 2024 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and the development of non-alcoholic steatohepatitis (NASH) might cause …

Kallistatin deficiency exacerbates neuronal damage after cardiac arrest

H Kim, GJ Suh, WY Kwon, KS Kim, YS Jung, T Kim… - Scientific Reports, 2024 - nature.com
The purpose of study was to evaluate that kallistatin deficiency causes excessive production
of reactive oxygen species and exacerbates neuronal injury after cardiac arrest. For in vitro …

Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats

M Gumus, E Gulbahce-Mutlu, O Unal… - Biological trace element …, 2024 - Springer
The aim of this study was to investigate how zinc deficiency and supplementation affect liver
markers including autotaxin, kallistatin, endocan, and zinc carrier proteins ZIP14 and ZnT9 …

HMGB1 in kidney diseases

Z Zhao, Z Hu, R Zeng, Y Yao - Life sciences, 2020 - Elsevier
High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in
numerous biological processes, and well known to trigger immune responses as the …

Kallistatin inhibits atherosclerotic inflammation by regulating macrophage polarization

B Li, Z Sheng, C Liu, L Qian, Y Wu, Y Wu, G Ma… - Human gene …, 2019 - liebertpub.com
Kallistatin (KS) has been recognized as a plasma protein with anti-inflammatory functions.
Macrophages are the primary inflammatory cells in atherosclerotic plaques. However, it is …

Inflammatory liver diseases and susceptibility to sepsis

H Lu - Clinical Science, 2024 - portlandpress.com
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …