Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

▪ Abstract The ability of animals to survive food deprivation is clearly of considerable survival
value. Unsurprisingly, therefore, all animals exhibit adaptive biochemical and physiological …

Ketogenic diets have been used as an approach to weight loss on the basis of the
theoretical advantage of a low-carbohydrate, high-fat diet. To evaluate the physiological and …

Acute and chronic injuries to the heart result in perturbation of intracellular calcium
signaling, which leads to pathological cardiac hypertrophy and remodeling …

Neurons containing melanin-concentrating hormone (MCH) are codistributed with neurons
containing orexin (Orx or hypocretin) in the lateral hypothalamus, a peptide and region …

Leptin is a key factor in the regulation of food intake and is an important factor in the
pathophysiology of obesity. However, more than a decade after the discovery of leptin in …

The effects of running wheel exercise and caloric restriction on the regulation of body
weight, adiposity, and hypothalamic neuropeptide expression were compared in diet …

The melanocortin system is implicated in the expression of many phenotypic traits. Activation
of the melanocortin MC1 receptor by melanocortin hormones induces the production of …

Overweight and obesity are the result of a chronic positive energy balance, and therefore the
only effective therapies are a diet which, on the long term, provides lower calories than the …

CART (cocaine-and amphetamine-regulated transcript) peptides are neuromodulators that
are involved in feeding, drug reward, stress, cardiovascular function, and bone remodeling …