Benzoxazines and benzoxazepines are nitrogen and oxygen‐containing six and seven‐
membered benzo‐fused heterocyclic scaffolds, respectively. Benzoxazepines and …

The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …

A highly efficient microwave-assisted copper (II)-catalyzed cyclization cascade was
established starting from readily accessible O/N-propargylated 2-hydroxy or 2 …

An efficient, diversity-oriented synthesis of oxazepino [5, 4-b] quinazolin-9-ones, 6 H-
chromeno [4, 3-b] quinolines, and dibenzo [b, h][1, 6] naphthyridines was established …

Diversity‐oriented synthesis (DOS) has become a powerful synthetic tool that facilitates the
construction of nature‐inspired and privileged chemical space, particularly for sp3‐rich non …

The design and synthesis of a quality compound library containing a small number of
skeletally diverse scaffolds, whose members rapidly deliver new chemical probes active …

Herein, we present a highly enantioselective desymmetrization of 3-substituted oxetanes
enabled by a confined chiral phosphoric acid. This metal-free process allows effective …

A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael
addition of azoles to α, β-unsaturated malonates using Cs2CO3 as a catalyst, has been …

Databases contain millions of reactions for compound synthesis, rendering selection of
reactions for forward synthetic design of small molecule screening libraries, such as DNA …

An expedient route to enantiopure, diastereomeric pyrrolopyrazinoquinazolinones was
developed following the discovery of a domino quinazolinone rearrangement …